Twentyone Hotel Rome Corridors photoTwentyone Hotel Rome Interior photoTwentyone Hotel Rome Exterior photo
Book on our site
Up to 10% cheaper
than Booking.com
Check rooms and rates
From82US$ /night
Check-in
16Apr2026Select date
Check-out
17Apr2026Select date
Rooms and Guests2 Guests, 1 Room
Key details

About the Hotel

Via Cola Di Rienzo 23, Rome, Italy, 00192
-
Close to Piazza del Popolo
Great
8.3
8.1
/10
3.3
3.7
/5

Location

Hotel Twentyone is strategically situated in the Prati district, halfway between St. Peter's Basilica and the Spanish Steps. The property is a short distance from the 'Lepanto' underground station, providing quick access to various attractions across Rome. It is within walking distance to notable sites such as the Vatican Museums, Piazza Navona, and Castel Sant'Angelo.

Dining

Bistrò 21 offers a selection of traditional Italian dishes made with top-quality ingredients for lunch and dinner. During the day, guests can enjoy a rich buffet featuring Mediterranean flavors. The evening aperitif at Bistrò 21 presents cocktails and an ample variety of appetizers.

Rooms

The hotel features 93 well-appointed rooms, including Deluxe double rooms and Junior Suites. Deluxe rooms on the fifth floor offer custom-made furnishings and a private terrace with iconic city views. Every Junior Suite includes a Jacuzzi and spacious accommodations, making them ideal for relaxation.

Family-Friendly Accommodations

Hotel Twentyone provides connected rooms that are suitable for families, featuring two bathrooms for convenience. The hotel arrangements allow families to enjoy ample space while maintaining privacy. Additionally, the welcoming atmosphere makes it a comfortable place for children.

Highlights

The hotel's central location makes it easy to explore cultural landmarks across Rome, from art galleries to fashion boutiques. Guests can enjoy tailored itineraries that blend art, history, and cultural experiences. Hotel Twentyone offers unique views of the city's historical architecture that enhances the overall experience.

Highlights

Location: halfway between St Peter's and the Spanish Steps

Dining: Bistrò 21 with traditional Italian cuisine

Rooms: Junior Suites with Jacuzzi

Family: connected rooms with two bathrooms

“Twentyone Hotel, set in Rome's Prati district, impressed me with its proximity to the Vatican and its dining, particularly the rooftop. While some rooms fall short on promised views, the location struck me as ideal for balancing city exploration with quieter moments. It presents a modern base for visitors focused on Vatican City.”
Hotel logo
James DavidEditor-in-Chief at Tohotel
View all

Select your room type

Twentyone Hotel offers a variety of rooms including double rooms, family rooms, and suites with breakfast, free cancelations, and special deals
Twin Room
2 persons
195 sq. feet 
2 Single beds
Shower
Heating
Triple Room
2 persons
240 sq. feet 
3 Single beds
Shower
Heating
Double Room
2 persons
195 sq. feet 
1 King-size bed
Shower
Heating
Deluxe Twin Room
2 persons
250 sq. feet 
2 Single beds
Shower
Heating
Click button to see more rooms
Show all rooms
Show all roomsLess

Price and Room Availability Calendar

Check availability and prices for your dates now!

Facilities

Twentyone Hotel offers amenities for your comfortable stay and unforgettable experiences
Facilities: Great
8.2/10Review score

General

  • Non-smoking rooms
  • Wi-Fi
  • Parking
  • Safe deposit box
  • 24-hour reception
  • Express check-in/ -out
  • No pets allowed
  • Rooms/ Facilities for disabled
  • Wheelchair access
  • Security
  • Luggage storage
  • Allergy-free rooms
  • Lift
  • Barber shop
  • Coffee shop
  • Smoke detectors
  • Electric vehicle charging station
  • Fire extinguishers
  • Key card access

Sports & Fitness

  • Fitness centre

Services

  • Paid airport shuttle
  • Room service
  • Housekeeping
  • Laundry
  • Dry cleaning
  • Tours/Ticket assistance
  • Welcome drink

Dining

  • In-room breakfast
  • Restaurant
  • Snack bar
  • Bar/ Lounge area
  • Packed lunches
  • Special diet menus

Business

  • Fax/Photocopying

Children

  • Cots
  • Children's buffet

Facilities for people with disabilities

  • Toilet for disabled
  • Bathroom for disabled

Spa & Leisure

  • Garden area
  • Leisure/ TV room

Room features

  • Air conditioning
  • Heating
  • Mini-bar
  • Soundproofed rooms
  • Sitting area
  • Terrace
  • Garden furniture
  • Tea and coffee facilities
  • Ironing facilities

Bathroom

  • Free toiletries
  • Sink

Media

  • Flat-screen TV
  • AM/FM alarm clock

Room decor

  • Carpeted floor
Show more

Dining Onsite

At Twentyone Hotel, guests are invited to immerse themselves in a dining journey that combines traditional Roman flavors with sophisticated international appeal. The vibrant setting of Vista promises a delightful array of vegetarian and international dishes, all served within a modern atmosphere perfect for any occasion.
Twentyone Hotel Rome Restaurant photo
Twentyone Hotel Rome Restaurant photo
Twentyone Hotel Rome Restaurant photo

Vista

International with traditional Roman and Italian influences
Ambiance
Modern dining space designed for comfort and warmth, enhancing the culinary experience
Key Offerings
A rich buffet with a selection of traditional Roman and classic Italian dishes, complemented by an extensive wine and champagne list. Vegetarian options are also available.
Reservation
Recommended for larger groups
Open daily from 11:30 AM to 11:30 PM

Twentyone Hotel Location

Via Cola Di Rienzo 23, Rome, Italy, 00192
Map view
Via Cola Di Rienzo 23, Rome, Italy, 00192
Nearby
Bridge
Castel Sant'Angelo
3500 ft
Square
Piazza del Popolo
2500 ft
Bridge
St. Angelo Bridge
3600 ft
Church
Church of Santa Maria del Popolo
2300 ft
Church
Basilica of Sant' Agostino
3400 ft
Restaurants
Bistro' 21
100 ft
Via Cola di Rienzo 23 Hotel Twenty One
Cantieri Bistrot
300 ft
Via Cola di Rienzo 16
Le Sicilianedde
300 ft
Via Cola di Rienzo
La Pinseria Prati
300 ft
Via Lucrezio Caro 60
Pasticceria Sanzini
500 ft
Via Valadier
VINO e FOCACCIA
500 ft
Piazza Cola di Rienzo 83/A
Grotta Azzurra
700 ft
Via Cicerone 62a
Quelli del bar Cicerone
600 ft
Via Cicerone 68
Ristorante Visconti 2.0
800 ft
Via Ennio Quirino Visconti 83
Explore Rome
Explore Rome
Top Attractions
Activities
Dining
Entertainment
Vatican Museums
Vatican Museums
20 minutes' walk
A vast collection of art and historical treasures, including the Sistine Chapel. Guided tours enhance the experience.
Saint Peter's Square
Saint Peter's Square
18 minutes' walk
An iconic plaza featuring stunning architecture and the famous obelisk. Great for photos and people-watching.
Piazza Navona
Piazza Navona
16 minutes' walk
A vibrant square known for its beautiful fountains and street artists. Perfect for enjoying gelato or coffee.
Castel Sant'Angelo
Castel Sant'Angelo
13 minutes' walk
A historic castle offering panoramic views of the city. A fascinating blend of history and art awaits.
Biking along the Tiber
10 minutes' walk
Bike rentals available. Explore scenic routes along the Tiber River, perfect for thrill-seekers.
Yoga in the Park
15 minutes' walk
Relax with outdoor yoga sessions at nearby parks. Suitable for all skill levels in a refreshing environment.
Bistro' 21
Bistro' 21
1 minutes' walk
Casual eatery with Italian favorites. Try their pasta dishes and enjoy a warm, inviting atmosphere.
Cantieri Bistrot
Cantieri Bistrot
2 minutes' walk
Offers a mix of Roman and Mediterranean dishes. Enjoy outdoor seating and daily specials.
Teatro dell'Opera di Roma
10 minutes' drive
A stunning opera house featuring world-class performances. Check the schedule for upcoming shows.
Piazza Navona Night Market
16 minutes' walk
Open during summer nights; local stalls and live musicians create a lively atmosphere for all ages.
Getting around
City Centre
Rome28 min  ·  1.4 mi
Airports
Ciampino (CIA)28 min  ·  11.6 mi
Fiumicino (FCO)45 min  ·  18.4 mi
Train
Flaminio Train Station10 min  ·  2700 ft
Underground
Lepanto Metro Station5 min  ·  1400 ft
Want to see Exclusive Early Booking Rate?
Get exlusive rates right now!
Check Rates
Property information and rules
Check-in
from 15:00-23:59
Check-out
from 07:00-11:00
Guest Parking
Private parking is possible on site (reservation might be needed) at EUR 35 per day.
Internet
Wireless internet is available in for free.
Breakfast
The hotel Twentyone provides visitors with a free full breakfast. 
Children & extra beds
There are no cots provided in a room. 
Pets
Pets are not allowed.
Languages
English, German, Spanish, Italian, Russian, Moldovan
Year renovated:
2009
Number of floors:
6
Number of rooms:
88

Reviews and Ratings

Feedback about Twentyone Hotel from previous guests about their experience.
Review summary
Based on recent reviews
Powered by AI
Twentyone Hotel is often praised for its convenient location, a pleasant walk to major attractions and only 15 minutes from the Vatican. Guests appreciate the well-equipped rooms featuring comfortable beds, flat-screen TVs, and complimentary Wi-Fi. Many enjoy the breakfast buffet with its fresh pastries, eggs, and fruit, though some have noted that the rooms can be a little dark. The hotel's proximity to nice restaurants and a quiet neighborhood also adds to its appeal.
Show moreShow less
Review score
Based on 1391 verified reviews
8.1/10
Great
85%
Recommend
Location
9.2/10
Staff
8.7/10
Paid Wi-Fi
7.1/10
Value for money
7.9/10
Pros
Excellent location
Helpful staff
Clean hotel
Good breakfast
Amazing shower
Cons
Small wardrobe
Thin walls
Odd-shaped room
Guest reviews
based on 1391 reviews
8.1/10
based on 1904 reviews
4/5
based on 3688 reviews
8.3/10
matthew from united kingdom
Single
double room
4 nights in November 2025
|
Reviewed:December 07, 2025
6/10

average stay with some issues

easy accesssoundproofing problemsinadequate solution
the location was acceptable, providing relatively easy access to major attractions.
the room i was assigned had soundproofing problems (i could hear street noise all night). the thermostat was set to heating and i could not adjust it. the staff offered a fan as the only solution, really inadequate.
0 Helpful
Nicole from Australia
Single
Double Room
3 nights in August 2025
|
Reviewed:September 14, 2025
7/10
good locationshort walkbreakfast varietyhard bedblack decormissing door lock
I found the location great. It was a short walk to the Vatican. I also appreciated the shops and restaurants nearby. Breakfast offered good variety.
The bed was quite hard. It was not comfortable for sleeping. The room felt really dark due to the black decor. There was no door lock on the bathroom door.
0 Helpful
Questions of the users
About Twentyone Hotel
What is the daily charge for parking at the hotel?
5 January 2024
The parking fee is € 25.00 per day.
Is there an airport shuttle service available?
12 February 2024
Yes, arrangements can be made for airport shuttle service, with rates varying based on the number of passengers.
What are the check-in and check-out times at the hotel?
20 March 2024
Check-in is at 14:00 and check-out is at 11:00.
Can luggage be stored at reception if checking in later in the day?
28 April 2024
Yes, luggage can be safely stored at the reception until check-in time.
Are there any TVs equipped with smart capabilities in the rooms?
15 May 2024
Unfortunately, there are no smart TVs available at the hotel.
Is the check-in process available around the clock?
22 June 2024
Yes, the reception operates 24 hours a day, seven days a week.
What type of dining options are available at the hotel?
10 July 2024
The hotel features a restaurant where guests can enjoy traditional Italian dishes for lunch and dinner.
I need a room and parking with disabled access. Are these facilities available?
18 August 2024
Yes, the hotel has rooms with disabled access and dedicated parking available.
Are hairdryers provided in the hotel rooms?
5 September 2024
Yes, all rooms come equipped with hairdryers.
How much does breakfast cost per person?
24 October 2024
Breakfast is available for € 10.00 per person per day.
Is it possible to arrange for transportation to the port and what would be the cost?
3 November 2024
Transportation to Civitavecchia port can be arranged, with taxi fare estimated at € 130.00.
Is smoking permitted on the balconies of the deluxe rooms?
12 December 2024
Yes, smoking is allowed on the balconies of the deluxe rooms and in designated smoking areas.

Next best alternative

Consider them for your next trip.
Check-in
16Apr2026Select date
Check-out
17Apr2026Select date
Rooms and Guests2 Guests, 1 Room