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From148US$ /night
Check-in
18Jan2026Select date
Check-out
19Jan2026Select date
Rooms and Guests2 Guests, 1 Room
Key details

About the Hotel

601 Main Street, Buffalo, New York, United States, 14203
-
Close to the city center
Very good
7.8
8.4
/10
4.3
4.0
/5

Rooms: Suites

Holiday Inn Express & Suites Buffalo Downtown has nice spacious rooms and all rooms are suites. Large two room suites include a king bed in the bedroom, a desk area, and a pullout couch in the living room. A door separates the bedroom from the living room for privacy. Each room features two 49" TVs, a microwave, a mini-fridge, and a Keurig coffee maker. You'll find bedside outlets, a plush duvet and your pick of pillows. All guestrooms include laptop-friendly workspaces, air conditioning, free WiFi, and separate sitting areas.

Dining: Free Breakfast

Breakfast at Holiday Inn Express & Suites Buffalo Downtown-Medical CTR is available from 6:00 AM. Dig into a free Express Start Breakfast with favorites such as a hot breakfast buffet with a pancake maker, cinnamon buns, eggs, meat, yogurt, fruits, cereal, breads, pastries, biscuits, juices, coffee, and tea. A TGI Friday's restaurant is located off the lobby level, serving lunch and dinner with a separate bar area.

Leisure and Entertainment

Guests can take advantage of the free trolley train at the hotel to Canalside. Take in a concert at the Town Ballroom or TRALF located within the same block. The Seneca Buffalo Creek Casino offers a free shuttle. The hotel has a 24-hour fitness center with cardio machines, free weights, stretch bands, and a boci ball.

Location and Transport

Holiday Inn Express & Suites Buffalo Downtown is 20 km from Buffalo Niagara International. The hotel is a 5-minute walk from Fountain Plaza and 20 minutes' walk from Buffalo, NY. The hotel is situated within 4 blocks of Roswell Park Comprehensive Cancer Center, John R. Oshei Children's Hospital, Buffalo General Hospital, Jacob's School of Medicine and Buffalo Hearing & Speech Center. The hotel is in the heart of the Theatre District. Interstate 190 heads directly into the heart of Buffalo.

Services Available

Check-in at Holiday Inn Express & Suites Buffalo Downtown-Medical CTR is from 3:00 PM. Free WiFi is available and guests can reach Platinum Elite status after 5 nights. A 24-hour business center featuring free printing is available. The hotel recommends parking at a city-owned garage 1.5 blocks from the hotel. A free hotel shuttle is available to and from the garage.

“This downtown Buffalo hotel sits in the heart of the Theater District, with the advantage of free transport to Canalside and other attractions. I noted the proximity to the passport agency is a boon for international travelers who may need urgent services. For those seeking a blend of work and play, this property appears to offer a solid, streamlined experience.”
Hotel logo
James DavidEditor-in-Chief at Tohotel
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Select your room type

The hotel offers a variety of rooms including double rooms, family rooms, and suites with breakfast, free cancelations, and special deals
Queen Suite Roll Shower Disability Access
2 persons
455 sq. feet 
1 King-size bed
Shower
Heating
One-Bedroom King Suite
2 persons
455 sq. feet 
1 King-size bed and 1 Sofa bed
Heating
Bathtub
Standard Room
2 persons
455 sq. feet 
1 Double bed
Heating
Bathtub
One-Bedroom Queen Room Mobility Accessible Tub Non-Smoking
2 persons
455 sq. feet 
1 King-size bed
Heating
Bathtub
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Price and Room Availability Calendar

Check availability and prices for your dates now!

Facilities

The hotel offers amenities for your comfortable stay and unforgettable experiences

General

  • No smoking on site
  • Free Wi-Fi
  • Car park
  • Handicap parking
  • Safe deposit box
  • 24-hour reception
  • Express check-in/ -out
  • No pets allowed
  • Rooms/ Facilities for disabled
  • Security
  • Luggage storage
  • Lift
  • Vending machines
  • Smoke detectors
  • Fire extinguishers
  • Key card access
  • Key access

Sports & Fitness

  • Fitness centre

Services

  • Housekeeping
  • Laundry
  • Dry cleaning

Business

  • Business centre
  • Fax/Photocopying

Children

  • Board games

Spa & Leisure

  • Leisure/ TV room

Room features

  • Air conditioning
  • Heating
  • Sitting area
  • Tea and coffee facilities

Bathroom

  • Free toiletries

Media

  • Flat-screen TV
  • AM/FM alarm clock

Room decor

  • Carpeted floor
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Location

601 Main Street, Buffalo, New York, United States, 14203
Map view
601 Main Street, Buffalo, New York, United States, 14203
Nearby
Event hall
Buffalo Convention Center
900 ft
Main and Chippewa Streets
Fountain Plaza
300 ft
One M&T Plaza
One M&T Plaza
400 ft
780 Main St at Edward St.
Saint Louis RC Church
1900 ft
Gallery
Western New York Book Arts Collaborative
1300 ft
Library
Buffalo and Erie County Public Library
1000 ft
West Chippewa Street
Chippewa Club Zone
800 ft
617 Main St
Market Arcade Building
200 ft
Gallery
CEPA Gallery
200 ft
535 Washington St
The Electric Tower
700 ft
Restaurants
EXPO Market
400 ft
617 Main St Ste 200
Breezy Burrito Co
700 ft
617 Main St
Prima Pizza Pasta
500 ft
396 Pearl St Corner of Chippewa St
Mighty Taco
600 ft
52 W Chippewa St
La Delicias Taqueria
900 ft
454 Pearl St
Tim Hortons
900 ft
424 Main St Rm 1102
Spot Coffee
1100 ft
225 Delaware Avenue
Tap House Pub & Grill
1000 ft
85 W Chippewa St
Jim's Steakout
1100 ft
92 W Chippewa St
Jake's Cafe
1300 ft
250 Delaware Ave
Explore Buffalo
Explore Buffalo's Highlights
Top Attractions
Activities
Dining
Entertainment
Buffalo Convention Center
Buffalo Convention Center
4 minutes' walk
A major venue for conventions and trade shows, featuring diverse events and exhibitions throughout the year.
Coca-Cola Field
Coca-Cola Field
14 minutes' walk
Home to the Buffalo Bisons, this baseball park offers a fun atmosphere with games during the season and community events.
McKinley Monument
McKinley Monument
10 minutes' walk
A grand tribute to President William McKinley, showcasing beautiful architecture and manicured grounds ideal for photos.
Buffalo and Erie County Naval and Military Park
Buffalo and Erie County Naval and Military Park
20 minutes' walk
An impressive naval park featuring historic ships and military exhibits, perfect for history enthusiasts and families.
Bike Riding along the Buffalo River
5 minutes' drive
Scenic bike paths along the river offer thrilling views. Rentals available nearby, suitable for all skill levels.
Yoga in the Park
4 minutes' drive
Relaxing yoga sessions held at local parks, with options for all levels. Check schedules for seasonal classes.
EXPO Market
EXPO Market
2 minutes' walk
A vibrant food hall with diverse vendors, offering everything from local sandwiches to international cuisines.
Breezy Burrito Co
Breezy Burrito Co
3 minutes' walk
Casual eatery known for its fresh burritos and quick bites. Great for a grab-and-go meal or relaxed lunch.
Prima Pizza Pasta
Prima Pizza Pasta
2 minutes' walk
Cozy spot serving authentic pizza and pasta dishes. The family-friendly atmosphere makes it perfect for gatherings.
KeyBank Center
KeyBank Center
25 minutes' walk
A premier sports and entertainment venue hosting concerts, hockey games, and family events throughout the year.
Fountain Plaza
Fountain Plaza
5 minutes' walk
A lively plaza often hosting live music events and outdoor movies, offering a vibrant community vibe suitable for all ages.
Getting around
City Centre
Buffalo3 min  ·  700 ft
Airports
Buffalo Niagara International Airport (BUF)24 min  ·  9.9 mi
Niagara Falls International Airport (IAG)49 min  ·  20.2 mi
Train
Buffalo, NY Station16 min  ·  4300 ft
Bus
Bus stop3 min  ·  700 ft
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Property information and rules
Check-in
from 15:00-23:59
Check-out
until 11 am
Guest Parking
Paid Public parking is possible at a location nearby.
Internet
is available in for free.
Breakfast
The hotel Holiday Inn Express & Suites Buffalo Downtown By Ihg serves a full breakfast for free. 
Children & extra beds
There are no cots provided in a room. 
Pets
Pets are not allowed.
Number of floors:
7
Number of rooms:
146
Former name
Comfort Suites
Questions of the users
About Holiday Inn Express & Suites Buffalo Downtown By Ihg
What are the parking options available near the hotel?
22 April 2024
There is no onsite parking, but a city parking garage is located just 1.5 blocks away, with rates typically between $9 and $14 per night.
Can I book a room with a debit card?
10 June 2024
Yes, debit cards are accepted as long as they are VISA or MASTERCARD.
Are there any rooms with two beds available?
15 May 2024
All accommodations are designed as king suites featuring a king bed in the bedroom along with a pullout sofa in the living room. No rooms with two separate beds are available.
Is a deposit required for incidentals during my stay?
03 September 2024
Yes, there is a hold of $50 placed per stay for incidentals at check-in.
What is the minimum age for check-in at the hotel?
12 July 2024
Guests must be 21 years or older to check in, and a valid photo ID is required.
Is Wi-Fi complimentary during my stay?
05 October 2024
Yes, complimentary Wi-Fi is available throughout the hotel.
Can cash payments be used for booking a room?
27 November 2024
Cash payments are accepted only at check-out. A credit card authorization for room and tax is required at check-in.
Is there an onsite bar or restaurant in the hotel?
08 December 2024
There is no bar within the hotel, but a TGI Friday's restaurant is located right next door, offering a variety of dining options.
What are the transportation options available to local attractions?
21 January 2025
There is no hotel transportation, but several attractions, including Shea's Theater, are within walking distance, and a free trolley train to Canalside is available right outside the hotel.
Can I make a reservation that allows free cancellations?
30 March 2025
Yes, most rates are refundable if cancelled within the designated cancellation period; details can be found during the booking process.

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