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From148US$ /night
Check-in
18Oct2025Select date
Check-out
19Oct2025Select date
Rooms and Guests2 Guests, 1 Room
Key details

About the Hotel

601 Main Street, Buffalo, New York, United States, 14203

Rooms: Suites

Holiday Inn Express & Suites Buffalo Downtown has nice spacious rooms and all rooms are suites. Large two room suites include a king bed in the bedroom, a desk area, and a pullout couch in the living room. A door separates the bedroom from the living room for privacy. Each room features two 49" TVs, a microwave, a mini-fridge, and a Keurig coffee maker. You'll find bedside outlets, a plush duvet and your pick of pillows. All guestrooms include laptop-friendly workspaces, air conditioning, free WiFi, and separate sitting areas.

Dining: Free Breakfast

Breakfast at Holiday Inn Express & Suites Buffalo Downtown-Medical CTR is available from 6:00 AM. Dig into a free Express Start Breakfast with favorites such as a hot breakfast buffet with a pancake maker, cinnamon buns, eggs, meat, yogurt, fruits, cereal, breads, pastries, biscuits, juices, coffee, and tea. A TGI Friday's restaurant is located off the lobby level, serving lunch and dinner with a separate bar area.

Leisure and Entertainment

Guests can take advantage of the free trolley train at the hotel to Canalside. Take in a concert at the Town Ballroom or TRALF located within the same block. The Seneca Buffalo Creek Casino offers a free shuttle. The hotel has a 24-hour fitness center with cardio machines, free weights, stretch bands, and a boci ball.

Location and Transport

Holiday Inn Express & Suites Buffalo Downtown is 20 km from Buffalo Niagara International. The hotel is a 5-minute walk from Fountain Plaza and 20 minutes' walk from Buffalo, NY. The hotel is situated within 4 blocks of Roswell Park Comprehensive Cancer Center, John R. Oshei Children's Hospital, Buffalo General Hospital, Jacob's School of Medicine and Buffalo Hearing & Speech Center. The hotel is in the heart of the Theatre District. Interstate 190 heads directly into the heart of Buffalo.

Services Available

Check-in at Holiday Inn Express & Suites Buffalo Downtown-Medical CTR is from 3:00 PM. Free WiFi is available and guests can reach Platinum Elite status after 5 nights. A 24-hour business center featuring free printing is available. The hotel recommends parking at a city-owned garage 1.5 blocks from the hotel. A free hotel shuttle is available to and from the garage.

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Select your room type

The hotel offers a variety of rooms including double rooms, family rooms, and suites with breakfast, free cancelations, and special deals
Queen Suite Roll Shower Disability Access
Max:
2 persons
42 m² 
Bed options:
1 King-size bed
Shower
Heating
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One-Bedroom King Suite
Max:
2 persons
42 m² 
Bed options:
1 King-size bed and 1 Sofa bed
Heating
Bathtub
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Standard Room
Max:
2 persons
42 m² 
Bed options:
1 Double bed
Heating
Bathtub
Check Prices
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Price and Room Availability Calendar

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Getting around

A list of all available modes of transport

City Centre
Buffalo200 m
Airports
Buffalo Niagara International (BUF) 15.9 km
Niagara Falls International (IAG) 32.5 km
Train
Buffalo, NY Station 1.3 km
Bus
Bus stop200 m

Facilities

The hotel offers amenities for your comfortable stay and unforgettable experiences

General

  • No smoking on site
  • Free Wi-Fi
  • Parking
  • Safe deposit box
  • 24-hour reception
  • Express check-in/ -out
  • No pets allowed
  • Rooms/ Facilities for disabled
  • Security
  • Luggage storage
  • Lift
  • Vending machines
  • Smoke detectors
  • Fire extinguishers
  • Key card access
  • Key access

Sports & Fitness

  • Fitness centre

Services

  • Housekeeping
  • Laundry
  • Dry cleaning

Business

  • Business centre
  • Fax/Photocopying

Children

  • Board games

Spa & Leisure

  • Leisure/ TV room

Room features

  • Air conditioning
  • Heating
  • Sitting area
  • Tea and coffee facilities

Bathroom

  • Free toiletries

Media

  • Flat-screen TV
  • AM/FM alarm clock

Room decor

  • Carpeted floor
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Location

601 Main Street, Buffalo, New York, United States, 14203
Map view
601 Main Street, Buffalo, New York, United States, 14203
Nearby
Event hall
Buffalo Convention Center
270 m
Main and Chippewa Streets
Fountain Plaza
80 m
One M&T Plaza
One M&T Plaza
100 m
780 Main St at Edward St.
Saint Louis RC Church
570 m
Gallery
Western New York Book Arts Collaborative
390 m
Library
Buffalo and Erie County Public Library
280 m
West Chippewa Street
Chippewa Club Zone
240 m
617 Main St
Market Arcade Building
40 m
Gallery
CEPA Gallery
50 m
535 Washington St
The Electric Tower
200 m
Restaurants
EXPO Market
120 m
617 Main St Ste 200
Breezy Burrito Co
190 m
617 Main St
Prima Pizza Pasta
130 m
396 Pearl St Corner of Chippewa St
Mighty Taco
170 m
52 W Chippewa St
La Delicias Taqueria
250 m
454 Pearl St
Tim Hortons
270 m
424 Main St Rm 1102
Spot Coffee
310 m
225 Delaware Avenue
Tap House Pub & Grill
300 m
85 W Chippewa St
Jim's Steakout
310 m
92 W Chippewa St
Jake's Cafe
380 m
250 Delaware Ave
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Check-in
18Oct2025Select date
Check-out
19Oct2025Select date
Rooms and Guests2 Guests, 1 Room