Book on our site
Up to 10% cheaper
than Booking.com
Check rooms and rates
From209US$ /night
Check-in
14Jan2026Select date
Check-out
15Jan2026Select date
Rooms and Guests2 Guests, 1 Room
Key details

About the Hotel

700 West Main Street, Louisville, Kentucky, United States, 40202
-
Steps from the waterfront
Great
8.7
9.3
/10
4.7
4.6
/5

Rooms & Suites

21c Louisville, located in Downtown Louisville, offers accommodations for families, couples, business, and solo travelers. Each guest room preserves the history of former bourbon and tobacco warehouses. Rooms feature ironing facilities, heating, air conditioning, tea and coffee facilities, a mini-bar, and trouser press. Select rooms include a patio and soundproofed walls. Bathrooms include free toiletries, and rooms have a flat-screen TV and carpeted floor. Quadruple rooms have city views and two beds. Triple rooms offer city views and one bed. Suites have a living room, a separate bedroom, a bathroom with free toiletries, a flat-screen TV, a mini-bar, a tea and coffee maker, and a wardrobe. The largest room features an open floor plan with a king-sized bed, a living and dining area, and a connecting king bedroom. One suite includes a well-fitted kitchen with a refrigerator, kitchenware, and a microwave. Some rooms include premium Bryte Restorative Sleep Bed + Experience, which allows for personalizing the sleep experience from temperature to firmness.

Dining Options

Proof on Main, led by Kentucky native and Executive Chef Cody Stone, offers menus that showcase a unique approach to Southern and Appalachian-inspired cuisine. The Proof on Main lounge includes the 21c Selects Private Barrel Program, and is ranked as one of the best bourbon bars in the country. Proof on Main's culinary team prepares catering menus tailored to specific needs. The hotel has events like the Fork & Bottle dinner series featuring guest distillers and spirits from throughout the region, and the annual Hog & Barrel dinner featuring Pappy Van Winkle.

Leisure & Entertainment

21c Louisville is a multi-venue contemporary art museum with changing exhibits and installations placed around its public spaces. Guests can sleep in a museum. It features more than 9,000 square feet of exhibition space where curated exhibitions and site-specific installations reflect contemporary culture. Works highlight the notion of the glitch, and posit new pathways and possibilities for the future. The museum is within a half mile of the Kentucky Museum of Art & Craft, Frazier International History Museum and Muhammad Ali Center. Local art in every form is displayed at Revelry Boutique Gallery, which showcases over 150 regional artists. Guests can view selected artworks from the 21c exhibition Still, Life, shared by 21c Museum Hotel Louisville manager Karen Gillenwater and art therapist Jennifer Kramer. There are site-specific installations. Events such as Fork & Bottle dinner series featuring guest distillers and spirits from throughout the region. Reflexology focuses on ' reflex points ' in the feet, hands and ears that relate to specific organs and glands in the body. A sports massage helps athletes prepare their bodies for optimal performance, recover after a big event, or function well during training. Guests can select a deep tissue massage to relieve the deeper structures of their muscle and connective tissue. There is also River City Tintype.

Location and Transportation

21c Museum Hotel Louisville is in Downtown Louisville near museums like the Muhammad Ali Center and the Louisville Slugger Museum & Factory. It is within a half mile of the Kentucky Museum of Art & Craft. Guests can access the free electric ZeroBus nearby, two roads down from the hotel, which takes a circulator route along Main and Market streets, visiting sites of the downtown area such as Whiskey Row and Slugger Field. The hotel is near historic Whiskey Row, where you'll find Old Forester, known as ' the first bottled bourbon.' It is near the Kentucky Performing Arts Center. Four large windows provide views of 7th Street, Main Street and the Ohio River. Landmarks nearby include Flame Run Glass Studio and Gallery (0.5 km), the Cathedral of the Assumption (0.5 km), Evan Williams Bourbon Experience (0.3 km), the Kentucky Museum of Art and Craft (0.3 km), Fourth Street Live (1 km), Louisville Slugger Field (1.5 km), The Frazier History Museum (0.3 km), and The Belvedere (0.3 km).

Hotel Services

21c Louisville is an event venue for celebrations, from unions and reunions to milestones and anniversaries, to product launches and corporate kickoffs. Dedicated event staff will help you treat your crew to an unforgettable occasion. There are four private galleries to accommodate meetings or events for groups of 10 to 60. The hotel is happy to get creative in reducing the environmental impact of your meeting or event, and event planners can provide guidance in planning an eco-conscious meeting or event.

“This downtown Louisville hotel intrigues with its commitment to contemporary art, displaying installations throughout the property, even within guest rooms. I noted the location near historic Whiskey Row and the Muhammad Ali Center as prime for exploring the city, in addition, the hotel restaurant, Proof on Main, emphasizes unique Southern cuisine and an active bourbon bar, setting it apart as a culinary destination. Lastly, their dedication to eco-friendly event planning adds a layer of responsible luxury to the experience.”
Hotel logo
James DavidEditor-in-Chief at Tohotel
View all

Select your room type

The hotel offers a variety of rooms including double rooms, family rooms, and suites with breakfast, free cancelations, and special deals
Room Balcony
2 persons
29 m² 
1 King-size bed
Shower
Coffee machine
Deluxe King Room
2 persons
31 m² 
1 King-size bed
Shower
Coffee machine
Corner Suite
2 persons
61 m² 
1 King-size bed
Shower
Coffee machine
Deluxe King Suite
2 persons
46 m² 
1 King-size bed
Shower
Coffee machine
Click button to see more rooms
Show all rooms
Show all roomsLess

Price and Room Availability Calendar

Check availability and prices for your dates now!

Facilities

The hotel offers amenities for your comfortable stay and unforgettable experiences

General

  • No smoking on site
  • Free Wi-Fi
  • Parking
  • Safe deposit box
  • 24-hour reception
  • Pets allowed
  • Rooms/ Facilities for disabled
  • Wheelchair access
  • Security
  • Luggage storage
  • Locker room
  • Allergy-free rooms
  • Lift
  • ATM/Cash machine
  • Smoke detectors
  • Electric vehicle charging station
  • Fire extinguishers

Sports & Fitness

  • Fitness centre
  • Yoga class

Guest Parking

  • Cookware/ Kitchen utensils

Services

  • Valet parking
  • Room service
  • Housekeeping
  • Laundry
  • Dry cleaning
  • Welcome drink

Dining

  • Restaurant
  • Bar/ Lounge area
  • Outdoor dining area

Business

  • Business centre
  • Meeting/ Banquet facilities
  • Fax/Photocopying

Children

  • Cots

Spa & Leisure

  • Spa & wellness centre
  • Sauna
  • Turkish bath
  • Steam room
  • Full body massage

Room features

  • Air conditioning
  • Heating
  • Mini-bar
  • Soundproofed rooms
  • Patio
  • Tea and coffee facilities
  • Ironing facilities

Bathroom

  • Free toiletries

Self-catering

  • Cookware/ Kitchen utensils

Media

  • Flat-screen TV

Room decor

  • Carpeted floor
Show more

Dining Onsite

Delight in the vibrant culinary scene at 21C Museum Hotel Louisville, where local American flavors meet contemporary flair. At Proof on Main, guests can savor innovative dishes crafted from the region's finest ingredients in a modern and inviting setting, complemented by immersive events throughout the year.
21C Museum Hotel Louisville Restaurant photo
21C Museum Hotel Louisville Restaurant photo
21C Museum Hotel Louisville Restaurant photo

Proof on Main

American
Ambiance
Modern and inviting, featuring contemporary design and artwork from the hotel's extensive collection.
Key Offerings
Indulge in seasonal dishes with a focus on local flavors, along with engaging events like the Fork & Bottle dinner series showcasing regional distillers and the annual Hog & Barrel dinner featuring Pappy Van Winkle.
Reservation
Recommended
Hours vary.

Location

700 West Main Street, Louisville, Kentucky, United States, 40202
Map view
700 West Main Street, Louisville, Kentucky, United States, 40202
Nearby
Museum
Louisville Slugger Museum & Bat Factory
180 m
Museum
Muhammad Ali Center
280 m
Museum
Kentucky Science Center
140 m
Museum
The Frazier History Museum
260 m
Museum
Kentucky Museum of Art and Craft
70 m
528 W Main St
Evan Williams Bourbon Experience
200 m
Gallery
Flame Run Glass Studio and Gallery
300 m
500 W Main St
The Belvedere
250 m
Night club
Jimmy Can't Dance
90 m
801 W Main St
Michter's Fort Nelson Distillery
150 m
Library
Sons of the American Revolution Genealogical Research Library
190 m
120 N 10th St
Kentucky Peerless Distilling Co
480 m
401 W River Rd
Belle of Louisville Riverboats
580 m
Restaurants
Proof On Main
10 m
702 West Main Street
Mussel & Burger Bar Downtown
60 m
113 S 7th St Located in Louisville's Central Business District
Bristol Bar & Grille
110 m
614 W Main St
Atlantic No. 5
160 m
605 W Main St Located in Louisville's Central Business District.
Los Aztecas Mexican Restaurant
180 m
445 E Market St
Vincenzo's Italian Restaurant
430 m
150 S 5th St
Jockey Silks Bourbon Bar
480 m
140 N 4th St 2nd Floor - West Tower
Dish on Market
470 m
434 W Market St
Quiznos
540 m
223 S 5th St
Swizzle Dinner & Drinks
530 m
140 N Fourth St 25th Floor
Cafe Magnolia
590 m
140 N 4th St Galt House Hotel
Explore Louisville
Local Insights Near 21C Museum Hotel Louisville
Top Attractions
Activities
Dining
Entertainment
Louisville Slugger Museum & Bat Factory
Louisville Slugger Museum & Bat Factory
3 minutes walking
Highlight of baseball history, showcasing iconic bats. Guided tours provide insights into craftsmanship and memorabilia.
Kentucky Science Center
Kentucky Science Center
2 minutes walking
Hands-on exhibits and a 4D theater make this science center engaging for families. Suitable for all ages.
Muhammad Ali Center
Muhammad Ali Center
4 minutes walking
Tribute to the legendary boxer, featuring interactive exhibits on Ali's life and humanitarian efforts.
The Frazier History Museum
The Frazier History Museum
4 minutes walking
Focus on Kentucky's history and culture with engaging exhibits, including artifacts from the Louisville area.
Waterfront Park
Waterfront Park
17 minutes walking
Spacious park ideal for jogging, picnics, and scenic river views. Perfect for relaxation or outdoor events.
Biking along the Big Four Bridge
25 minutes walking
Stunning views while biking across this iconic bridge. Rentals available nearby for thrill-seekers.
Proof On Main
Proof On Main
1 minute walking
Unique art-infused dining experience with farm-to-table dishes and an extensive bourbon selection.
Mussel & Burger Bar Downtown
Mussel & Burger Bar Downtown
1 minute walking
Casual eatery known for gourmet burgers and fresh mussels in a vibrant setting. Reservations recommended.
Bristol Bar & Grille
Bristol Bar & Grille
2 minutes walking
Local favorite offering comfort food with a twist. Family-friendly atmosphere; gluten-free options available.
KFC Yum Center
KFC Yum Center
9 minutes walking
Multi-purpose arena hosting concerts and sports events. Check schedule for upcoming shows and games.
Fourth Street Live!
10 minutes walking
Lively entertainment district featuring live music, bars, and dining. Great spot for nightlife and events.
Getting around
City Centre
Louisville23 min  ·  1.9 km
Airports
Louisville International Airport (SDF)18 min  ·  11.9 km
Want to see Exclusive Early Booking Rate?
Get exlusive rates right now!
Check Rates
Property information and rules
Check-in
from 16:00-23:59
Check-out
until 11 am
Guest Parking
No parking available.
Internet
is available in for free.
Children & extra beds
Maximum capacity of extra beds in a room is 1. 
Pets
Pets are allowed on request.
Year renovated:
2006
Number of floors:
4
Number of rooms:
96
Former name
21c Museum Hotel
Questions of the users
About 21C Museum Hotel Louisville
Are there any rooms with balconies available for guests?
15 November 2024
The Luxury Kings rooms do not feature balconies, but there are two balcony suites and one penthouse with a spacious 2000 sq. ft. terrace available for booking.
What are the parking options for visitors at the hotel?
20 December 2024
The hotel provides valet parking for a fee of $32 per night, which allows unlimited access to your vehicle. Additionally, self-parking is available on nearby streets or in a parking garage located at 7th and Market.
What is the cost for bringing two small dogs to the hotel?
5 February 2025
There is a pet fee of $75 per room for bringing in two small dogs. This fee covers their stay at the hotel.
Are there special arrangements for groups attending weddings?
10 March 2025
Yes, there are options for room blocks and special arrangements for wedding parties. For more details, it is recommended to reach out to the hotel's sales team.
Do the rooms with balconies offer views of the river?
25 April 2025
The balcony rooms overlook 7th Street, while the Corner Suites provide excellent views of the river but do not feature balconies.
Can you confirm if there are any available rooms with bathtubs?
30 May 2025
All Deluxe Double Rooms come equipped with bathtubs, ensuring a relaxing experience during your stay.
Does the hotel have any rooms that include soaking tubs?
15 June 2025
Soaking tubs are not available in the guest rooms; however, some rooms come with standard size bathtubs.
Are there honeymoon suites or packages for couples?
22 July 2025
The hotel offers a 'Love Birds Package' that can transform any suite into a honeymoon suite, complete with a $100 dining credit at Proof on Main, along with sparkling wine and chocolate-covered strawberries in the room upon arrival.
What is the pricing structure for breakfast at the hotel?
18 August 2025
Breakfast is served as a sit-down option with individual pricing. If a breakfast package is booked, guests receive an $18 credit per person per day towards breakfast.
Are rollaway beds available for additional guests?
12 September 2025
Yes, rollaway beds can be requested, but availability is limited. It's best to contact the hotel directly to secure one at the time of booking.
Do the guest rooms come with refrigerators?
27 October 2025
Guest rooms are equipped with stocked minibars, but they do not have empty refrigerators. If needed, a mini-fridge can be added upon request by contacting the hotel.
Can you tell me about the dining options available at the hotel?
14 November 2025
The on-site restaurant Proof on Main offers a unique culinary experience with a focus on southern and Appalachian-inspired cuisine, crafted by Kentucky native and Executive Chef Cody Stone.

Next best alternative

Consider them for your next trip.
Check-in
14Jan2026Select date
Check-out
15Jan2026Select date
Rooms and Guests2 Guests, 1 Room
Need more options?
Check Top hotels near 21C Museum Hotel Louisville
The Grady Hotel Louisville Exterior photo
Mobile-only price

The Grady Hotel Louisville

9.2
Perfect347 reviews
150m from property
USD 296USD 266
per night
Holiday Inn Express & Suites Downtown Louisville By Ihg Exterior photo
Mobile-only price

Holiday Inn Express & Suites Downtown Louisville By Ihg

8.4
Great619 reviews
222m from property
USD 95USD 85
per night
Galt House Hotel, A Trademark Collection Hotel Louisville Exterior photo
Mobile-only price

Galt House Hotel, A Trademark Collection Hotel Louisville

8.7
Great2259 reviews
485m from property
USD 119USD 107
per night